Bus tickets La Serena to Santiago, RM from £6

Find a coach from La Serena to Santiago, RM: Compare 12 companies
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Which bus from La Serena to Santiago, RM is the best?

Check the bus schedule for La Serena to Santiago, RM. Here is a selection of the cheapest coach trips for the next days from bus operators like Cikbus Elité, FlixBus or Pluss Chile. To see the full timetable for all coaches just use or search and compare.

today
from £6
tomorrow
from £6
Wednesday
from £6
Thursday
from £6
Friday
from £6
Saturday
from £6
Sunday
from £6

Cheapest bus trips today

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £6
  • Cikbus Elité
    7h 0m
    0
    11:00
    La Serena
    Bus Station
    18:00
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £8
  • Nueva Andimar Vip
    6h 10m
    0
    04:20
    La Serena
    Bus Station
    10:30
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    Premium Economy
    £10
  • Condor Bus
    6h 15m
    0
    16:35
    La Serena
    Bus Station
    22:50
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    £10
  • Turbus
    6h 15m
    0
    16:35
    La Serena
    Bus Station
    22:50
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £10

Cheapest bus trips tomorrow

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £6
  • Turbus
    5h 45m
    0
    17:55
    La Serena
    Bus Stop
    23:40
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £6
  • Pluss Chile
    6h 40m
    0
    00:05
    La Serena
    Bus Station
    06:45
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    £9
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Bus Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £9
  • Nueva Andimar Vip
    6h 10m
    0
    00:50
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    Premium Economy
    £10

Cheapest bus trips Wednesday

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £6
  • Turbus
    6h 30m
    0
    16:00
    La Serena
    Bus Stop
    22:30
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £6
  • Cikbus Elité
    5h 10m
    0
    00:50
    La Serena
    Bus Station
    06:00
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £8
  • Pluss Chile
    6h 40m
    0
    00:05
    La Serena
    Bus Station
    06:45
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    £9
  • FlixBus
    6h 5m
    0
    14:00
    La Serena
    Bus Station
    20:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £9

Cheapest bus trips Thursday

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £6
  • Turbus
    6h 15m
    0
    04:50
    La Serena
    Bus Stop
    11:05
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £6
  • FlixBus
    6h 5m
    0
    10:00
    La Serena
    Bus Station
    16:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £6
  • Cikbus Elité
    7h 20m
    0
    01:10
    La Serena
    Bus Station
    08:30
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £8
  • Pluss Chile
    6h 40m
    0
    00:05
    La Serena
    Bus Station
    06:45
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    £9

Cheapest bus trips Friday

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £6
  • Turbus
    6h 30m
    0
    16:00
    La Serena
    Bus Stop
    22:30
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £6
  • Cikbus Elité
    7h 15m
    0
    12:35
    La Serena
    Bus Station
    19:50
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £7
  • Pluss Chile
    6h 30m
    0
    02:30
    La Serena
    Bus Station
    09:00
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    £9
  • FlixBus
    6h 5m
    0
    16:00
    La Serena
    Bus Station
    22:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £9

Cheapest bus trips Saturday

Prices are for one way and one person
  • Buses Romani
    6h 15m
    0
    00:45
    La Serena
    Bus Station
    07:00
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    £6
  • Condor Bus
    6h 55m
    0
    23:00
    La Serena
    Bus Station
    05:55
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    £6
  • Turbus
    6h 15m
    0
    04:50
    La Serena
    Bus Stop
    11:05
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £6
  • Cikbus Elité
    7h 0m
    0
    09:30
    La Serena
    Bus Stop
    16:30
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    £7
  • FlixBus
    6h 5m
    0
    14:00
    La Serena
    Bus Station
    20:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £8

Cheapest bus trips Sunday

Prices are for one way and one person
  • Turbus
    6h 5m
    0
    00:30
    La Serena
    Bus Stop
    06:35
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    £6
  • Condor Bus
    6h 15m
    0
    01:45
    La Serena
    Bus Station
    08:00
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    £6
  • Cikbus Elité
    7h 20m
    0
    01:10
    La Serena
    Bus Station
    08:30
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    £8
  • FlixBus
    6h 5m
    0
    06:00
    La Serena
    Bus Station
    12:05
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    £9
  • Nueva Andimar Vip
    6h 10m
    0
    03:20
    La Serena
    Bus Station
    09:30
    Santiago, RM
    Sur Bus Station
    0
    Nueva Andimar Vip
    Premium Economy
    £10

What is the best day and time to travel by bus between La Serena and Santiago, RM?

Here is the frequency of all coach connections from La Serena to Santiago, RM. See on which day of the week you have more travel options and what time you have more bus trips to choose from.
Friday is the busiest day, with more than 285 daily coaches from La Serena to Santiago, RM. Tuesday has instead the fewest connections, with only 137 daily coaches between La Serena and Santiago, RM.
The busiest time of the day is the Morning, with 466 coaches from La Serena to Santiago, RM, while Evening sees the fewest connections between La Serena and Santiago, RM, with 175 offers.

All facts for La Serena to Santiago, RM bus at a glance

Compare all coach operators like Cikbus Elité, FlixBus and Pluss Chile that travel daily 197 times by bus from La Serena to Santiago, RM in one click. Book your La Serena to Santiago, RM bus ticket starting from £6!

Cheapest Bus £6
Fastest Bus 5h 5m
Earliest Coach 00:30
Latest Coach 23:59
Daily Bus Connections 197 Ø
Distance 397.3 km
Coach Companies Cikbus Elité, FlixBus, Pluss Chile, Turbus, Pullman San Andres, Nueva Andimar Vip, Pullman Bus, Buses Romani, Condor Bus, Cormar Bus and 2 more.

What are the cheapest coach tickets from La Serena to Santiago, RM?

Every day, 197 buses from 12 coach companies leave La Serena for Santiago, RM. Check the table below to find the cheapest prices for coach tickets for this route, starting from 31/03/2025 and for the following days. Make sure get the cheapest bus ticket!

Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
Monday 31/03
£6
Tuesday 01/04
£6
Wednesday 02/04
£9
Thursday 03/04
£6
Friday 04/04
£6
Saturday 05/04
£7
Sunday 06/04
£6
Monday 07/04
£6
Tuesday 08/04
£6
Wednesday 09/04
£6
Thursday 10/04
£6
Friday 11/04
£6
Saturday 12/04
£6
Sunday 13/04
£6
Monday 14/04
£6
Tuesday 15/04
£6
Wednesday 16/04
£6
Thursday 17/04
£10
Friday 18/04
£6
Saturday 19/04
£6
Sunday 20/04
£10
Monday 21/04
£10
Tuesday 22/04
£6
Wednesday 23/04
£6
Thursday 24/04
£6
Friday 25/04
£8
Saturday 26/04
£6
Sunday 27/04

The cheapest time to travel from La Serena to Santiago, RM

See here on which day and which time of the day you can find the cheapest bus ticket from La Serena to Santiago, RM, for the next 30 days.
With a price starting from £6, Tuesday is the cheapest day for a coach from La Serena to Santiago, RM. Monday instead is the most expensive day with prices starting from £6.
Morning is the cheapest day time for bus tickets from La Serena to Santiago, RM, with £6. Morning is the most expensive time of the day with prices starting from £6.

How to save money travelling from La Serena to Santiago, RM

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying higher prices for your trip? Plan your bus trips smartly. Here are a few hacks to save money on your coach journey.

Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the coach from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from La Serena to Santiago, RM are also emptier.

Check for bus deals and promotions for all bus companies in this route. On CheckMyBus we show special offers directly in the coach trip on our search. Sign-up and check or deals sections and get notifications on our latest travel hacks.

What are the most popular bus companies from La Serena to Santiago, RM?

These are the most booked bus companies by our users on the La Serena to Santiago, RM timetable.

FlixBus from La Serena to Santiago, RM

FlixBus

Here you will find the key facts about the FlixBus bus route La Serena to Santiago, RM:

Cheapest Price £6
Fastest Coach 5h 6m
Earliest Coach 06:00
Last Coach 23:59
Daily Connections 27 Ø
Found on 31/03/2025
In total 12 operators offer buses for this route. Find all bus timetables for them. Each coach company has a dedicated cancellation policy and possibilities for transport luggage on the bus. Check also special conditions to travel with kids or coach cards with rebates.

Latest reviews for coach companies on the route La Serena - Santiago, RM

Pluss Chile
Esteban Guerrero, 29/01/2025

Compré un pasaje de 6 horas en salón premium adelante en el parabrisas no había nada de espacio. Ultima vez que viajo en plus chile

All bus stations and stops in La Serena and Santiago, RM

Here is a map with all coach stations in La Serena and Santiago, RM. Compare which stop is closest to your destination to save time to find the fastest buses and connections.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from La Serena to Santiago, RM? Compare all modes of transports from La Serena to Santiago, RM.

All you need to know when you travel by bus from La Serena to Santiago, RM

Check all information on comfort and services on the coaches from La Serena to Santiago, RM. Which seat classes are available or what are the amenities of operators on your coach trip? Below you´ll find answers to your questions.

FAQs for La Serena to Santiago, RM bus

How much does a La Serena Santiago, RM coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the La Serena Santiago, RM bus trip is available from £6 and takes 5h 45m. Compare offers and save money!

How much could I save by comparing buses from La Serena to Santiago, RM?

This connection is offered by 12 companies with ticket prices ranging from £6 to £26. Therefore, we suggest booking your ticket as soon as possible to ensure you’ll get the cheapest bus trip to Santiago, RM.

How many connections are available for the La Serena Santiago, RM route on average every day?

Each day, the bus route from La Serena to Santiago, RM is offered by roughly 197 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Santiago, RM from La Serena take?

The quickest coach from La Serena to Santiago, RM is provided by Cormar Bus and takes 5h 5m. Coach tickets for this connection cost £13. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from La Serena to Santiago, RM?

The earliest bus to Santiago, RM departs from La Serena at 00:30. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from La Serena to Santiago, RM?

The latest bus to Santiago, RM departs from La Serena at 23:59. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the La Serena Santiago, RM route?

Passengers looking to travel from La Serena to Santiago, RM can travel with Cikbus Elité, FlixBus and Pluss Chile. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between La Serena and Santiago, RM?

You can check all the direct connections between La Serena and Santiago, RM by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Cikbus Elité, FlixBus and Pluss Chile.

What can I take with me on the bus to Santiago, RM from La Serena?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the La Serena Santiago, RM bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Santiago, RM bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Santiago, RM on your planned travel date.

Available seat classes which are offered on the bus route La Serena to Santiago, RM

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

Business
Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

More bus routes to La Serena and to Santiago, RM

Here’s an overview of the most popular bus routes to La Serena and to Santiago, RM. Simply click on the connection of your choice, and you’ll find all the details about your bus route!
Buses Valparaíso (CL) to La Serena Buses Valparaíso (CL) to La Serena
Antofagasta to La Serena coach Antofagasta to La Serena coach
Bus to La Serena from Iquique Bus to La Serena from Iquique
Coach to La Serena from Arica, AP Coach to La Serena from Arica, AP
Buses Iquique to Santiago, RM Buses Iquique to Santiago, RM
Bus to Santiago, RM from Coquimbo Bus to Santiago, RM from Coquimbo
Coach Concepción to Santiago, RM Coach Concepción to Santiago, RM
Coaches Copiapó to Santiago, RM Coaches Copiapó to Santiago, RM
Popular Airport Transfers to La Serena and to Santiago, RM
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