Bus and Coach from Rome to Brussels: Compare all prices

Compare all timetables for the bus from Rome to Brussels

Here is a selection of the cheapest bus trips from the schedule from Rome to Brussels from various bus operators like FlixBus for the next days.

today

£109

tomorrow

£105

Wednesday

£98

Thursday

Friday

£145

Saturday

£146

Sunday

£148

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	24h 55m	10:40	Rome	Tiburtina Bus Station	11:35	Brussels	North Station	Economy	£109	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 10:40:00 to North Station, Brussels (Belgium) arriving at 23/12/2025 11:35:00. 50 Economy ticket for £109 per person are available. Travel duration is 24h 55m
FlixBus	32h 50m	23:50	Rome	Tiburtina Bus Station	08:40	Brussels	North Station	Economy	£117	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 23:50:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 08:40:00. 50 Economy ticket for £117 per person are available. Travel duration is 32h 50m
FlixBus	33h 30m	22:45	Rome	Tiburtina Bus Station	08:15	Brussels	Midi Bus Station	Economy	£118	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 22/12/2025 22:45:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 08:15:00. 50 Economy ticket for £118 per person are available. Travel duration is 33h 30m
FlixBus	30h 5m	17:25	Rome	Anagnina Bus Station	23:30	Brussels	Midi Bus Station	Economy	£120	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 22/12/2025 17:25:00 to Midi Bus Station, Brussels (Belgium) arriving at 23/12/2025 23:30:00. 50 Economy ticket for £120 per person are available. Travel duration is 30h 5m
FlixBus	26h 30m	13:05	Rome	Anagnina Bus Station	15:35	Brussels	Midi Bus Station	Economy	£134	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 22/12/2025 13:05:00 to Midi Bus Station, Brussels (Belgium) arriving at 23/12/2025 15:35:00. 50 Economy ticket for £134 per person are available. Travel duration is 26h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	33h 30m	22:45	Rome	Tiburtina Bus Station	08:15	Brussels	Midi Bus Station	Economy	£105	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 23/12/2025 22:45:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 08:15:00. 50 Economy ticket for £105 per person are available. Travel duration is 33h 30m
FlixBus	32h 50m	23:50	Rome	Tiburtina Bus Station	08:40	Brussels	North Station	Economy	£110	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 23/12/2025 23:50:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 08:40:00. 50 Economy ticket for £110 per person are available. Travel duration is 32h 50m
FlixBus	27h 25m	00:10	Rome	Tiburtina Bus Station	03:35	Brussels	North Station	Economy	£114	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 23/12/2025 00:10:00 to North Station, Brussels (Belgium) arriving at 24/12/2025 03:35:00. 50 Economy ticket for £114 per person are available. Travel duration is 27h 25m
FlixBus	27h 30m	08:50	Rome	Tiburtina Bus Station	12:20	Brussels	Midi Bus Station	Economy	£115	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 23/12/2025 08:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 12:20:00. 50 Economy ticket for £115 per person are available. Travel duration is 27h 30m
FlixBus	29h 40m	10:10	Rome	Tiburtina Bus Station	15:50	Brussels	Midi Bus Station	Economy	£115	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 23/12/2025 10:10:00 to Midi Bus Station, Brussels (Belgium) arriving at 24/12/2025 15:50:00. 50 Economy ticket for £115 per person are available. Travel duration is 29h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	32h 25m	22:55	Rome	Tiburtina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£98	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 24/12/2025 22:55:00 to Midi Bus Station, Brussels (Belgium) arriving at 26/12/2025 07:20:00. 50 Economy ticket for £98 per person are available. Travel duration is 32h 25m
FlixBus	29h 10m	09:30	Rome	Tiburtina Bus Station	14:40	Brussels	North Station	Economy	£103	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 24/12/2025 09:30:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 14:40:00. 50 Economy ticket for £103 per person are available. Travel duration is 29h 10m
FlixBus	32h 5m	00:10	Rome	Tiburtina Bus Station	08:15	Brussels	Midi Bus Station	Economy	£103	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 24/12/2025 00:10:00 to Midi Bus Station, Brussels (Belgium) arriving at 25/12/2025 08:15:00. 50 Economy ticket for £103 per person are available. Travel duration is 32h 5m
FlixBus	31h 45m	23:35	Rome	Anagnina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£104	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 24/12/2025 23:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 26/12/2025 07:20:00. 50 Economy ticket for £104 per person are available. Travel duration is 31h 45m
FlixBus	27h 40m	13:05	Rome	Anagnina Bus Station	16:45	Brussels	North Station	Economy	£105	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 24/12/2025 13:05:00 to North Station, Brussels (Belgium) arriving at 25/12/2025 16:45:00. 50 Economy ticket for £105 per person are available. Travel duration is 27h 40m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	32h 25m	22:55	Rome	Tiburtina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£145	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 26/12/2025 22:55:00 to Midi Bus Station, Brussels (Belgium) arriving at 28/12/2025 07:20:00. 50 Economy ticket for £145 per person are available. Travel duration is 32h 25m
FlixBus	29h 45m	12:10	Rome	Tiburtina Bus Station	17:55	Brussels	Midi Bus Station	Economy	£149	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 26/12/2025 12:10:00 to Midi Bus Station, Brussels (Belgium) arriving at 27/12/2025 17:55:00. 50 Economy ticket for £149 per person are available. Travel duration is 29h 45m
FlixBus	32h 50m	23:50	Rome	Tiburtina Bus Station	08:40	Brussels	North Station	Economy	£153	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 26/12/2025 23:50:00 to North Station, Brussels (Belgium) arriving at 28/12/2025 08:40:00. 50 Economy ticket for £153 per person are available. Travel duration is 32h 50m
FlixBus	31h 45m	23:35	Rome	Anagnina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£154	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 26/12/2025 23:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 28/12/2025 07:20:00. 50 Economy ticket for £154 per person are available. Travel duration is 31h 45m
FlixBus	24h 0m	08:30	Rome	Tiburtina Bus Station	08:30	Brussels	North Station	Economy	£156	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 26/12/2025 08:30:00 to North Station, Brussels (Belgium) arriving at 27/12/2025 08:30:00. 50 Economy ticket for £156 per person are available. Travel duration is 24h 0m

Did you know that if you travel from Rome to Brussels via Scandicci, you can save more than £41? You can find the corresponding connections below.
- INFOBUS
  
  22h 40m
  
  0
  
  10:00
  
  Rome
  Tiburtina Bus Station
  
  13:15
  
  Scandicci
  Bus Stop
  
  0
  
  Economy
  
  £17
  
  A Bus from INFOBUS goes from Tiburtina Bus Station, Rome (Italy) at 27/12/2025 10:00:00 to Bus Stop, Scandicci (Italy) arriving at 27/12/2025 13:15:00. 50 Economy ticket for £17 per person are available. Travel duration is 3h 15m
- INFOBUS
  
  18h 25m
  
  0
  
  14:15
  
  Scandicci
  Bus Stop
  
  08:40
  
  Brussels
  Midi Bus Station
  
  0
  
  Economy
  
  £87
  
  A Bus from INFOBUS goes from Bus Stop, Scandicci (Italy) at 27/12/2025 14:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 28/12/2025 08:40:00. 50 Economy ticket for £87 per person are available. Travel duration is 18h 25m
Travel Time is 1h 20m shorter, and you will save £41

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	30h 5m	17:25	Rome	Anagnina Bus Station	23:30	Brussels	Midi Bus Station	Economy	£146	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 27/12/2025 17:25:00 to Midi Bus Station, Brussels (Belgium) arriving at 28/12/2025 23:30:00. 50 Economy ticket for £146 per person are available. Travel duration is 30h 5m
FlixBus	22h 30m	10:10	Rome	Tiburtina Bus Station	08:40	Brussels	North Station	Economy	£147	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 27/12/2025 10:10:00 to North Station, Brussels (Belgium) arriving at 28/12/2025 08:40:00. 50 Economy ticket for £147 per person are available. Travel duration is 22h 30m
FlixBus	32h 25m	22:55	Rome	Tiburtina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£151	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 27/12/2025 22:55:00 to Midi Bus Station, Brussels (Belgium) arriving at 29/12/2025 07:20:00. 50 Economy ticket for £151 per person are available. Travel duration is 32h 25m
FlixBus	24h 25m	11:10	Rome	Anagnina Bus Station	11:35	Brussels	North Station	Economy	£152	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 27/12/2025 11:10:00 to North Station, Brussels (Belgium) arriving at 28/12/2025 11:35:00. 50 Economy ticket for £152 per person are available. Travel duration is 24h 25m
FlixBus	31h 45m	23:35	Rome	Anagnina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£153	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 27/12/2025 23:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 29/12/2025 07:20:00. 50 Economy ticket for £153 per person are available. Travel duration is 31h 45m

Did you know that if you travel from Rome to Brussels via Scandicci, you can save more than £64? You can find the corresponding connections below.
- INFOBUS
  
  33h 0m
  
  0
  
  23:40
  
  Rome
  Tiburtina Bus Station
  
  02:55
  
  Scandicci
  Bus Stop
  
  0
  
  Economy
  
  £17
  
  A Bus from INFOBUS goes from Tiburtina Bus Station, Rome (Italy) at 27/12/2025 23:40:00 to Bus Stop, Scandicci (Italy) arriving at 28/12/2025 02:55:00. 50 Economy ticket for £17 per person are available. Travel duration is 3h 15m
- INFOBUS
  
  18h 25m
  
  0
  
  14:15
  
  Scandicci
  Bus Stop
  
  08:40
  
  Brussels
  Midi Bus Station
  
  0
  
  Economy
  
  £66
  
  A Bus from INFOBUS goes from Bus Stop, Scandicci (Italy) at 28/12/2025 14:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 29/12/2025 08:40:00. 50 Economy ticket for £66 per person are available. Travel duration is 18h 25m
Travel time is 10h 30m longer, but you will save £64

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	32h 25m	22:55	Rome	Tiburtina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£148	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 28/12/2025 22:55:00 to Midi Bus Station, Brussels (Belgium) arriving at 30/12/2025 07:20:00. 50 Economy ticket for £148 per person are available. Travel duration is 32h 25m
FlixBus	31h 45m	23:35	Rome	Anagnina Bus Station	07:20	Brussels	Midi Bus Station	Economy	£151	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 28/12/2025 23:35:00 to Midi Bus Station, Brussels (Belgium) arriving at 30/12/2025 07:20:00. 50 Economy ticket for £151 per person are available. Travel duration is 31h 45m
FlixBus	24h 0m	08:30	Rome	Tiburtina Bus Station	08:30	Brussels	North Station	Economy	£164	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 28/12/2025 08:30:00 to North Station, Brussels (Belgium) arriving at 29/12/2025 08:30:00. 50 Economy ticket for £164 per person are available. Travel duration is 24h 0m
FlixBus	27h 30m	08:50	Rome	Tiburtina Bus Station	12:20	Brussels	Midi Bus Station	Economy	£165	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 28/12/2025 08:50:00 to Midi Bus Station, Brussels (Belgium) arriving at 29/12/2025 12:20:00. 50 Economy ticket for £165 per person are available. Travel duration is 27h 30m
FlixBus	26h 50m	00:10	Rome	Tiburtina Bus Station	03:00	Brussels	North Station	Economy	£166	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 28/12/2025 00:10:00 to North Station, Brussels (Belgium) arriving at 29/12/2025 03:00:00. 50 Economy ticket for £166 per person are available. Travel duration is 26h 50m

Did you know that if you travel from Rome to Brussels via Scandicci, you can save more than £66? You can find the corresponding connections below.
- INFOBUS
  
  33h 0m
  
  0
  
  23:40
  
  Rome
  Tiburtina Bus Station
  
  02:55
  
  Scandicci
  Bus Stop
  
  0
  
  Economy
  
  £17
  
  A Bus from INFOBUS goes from Tiburtina Bus Station, Rome (Italy) at 27/12/2025 23:40:00 to Bus Stop, Scandicci (Italy) arriving at 28/12/2025 02:55:00. 50 Economy ticket for £17 per person are available. Travel duration is 3h 15m
- INFOBUS
  
  18h 25m
  
  0
  
  14:15
  
  Scandicci
  Bus Stop
  
  08:40
  
  Brussels
  Midi Bus Station
  
  0
  
  Economy
  
  £66
  
  A Bus from INFOBUS goes from Bus Stop, Scandicci (Italy) at 28/12/2025 14:15:00 to Midi Bus Station, Brussels (Belgium) arriving at 29/12/2025 08:40:00. 50 Economy ticket for £66 per person are available. Travel duration is 18h 25m
Travel time is 9h 0m longer, but you will save £66

Best Price Offer: The price for the cheapest coach from Rome to Brussels is £55 on 11/01/2026. Flexible travellers save on ticket prices.

Frequency of bus connections between Rome and Brussels

See here how frequent the connections between Rome and Brussels are, during different times and days of the week.

Friday is the busiest day, with more than 19 daily coaches from Rome to Brussels. Monday has instead the fewest connections, with only 9 daily coaches between Rome and Brussels.

The busiest time of the day is the Afternoon, with 34 coaches from Rome to Brussels, while Night sees the fewest connections between Rome and Brussels, with 10 offers.

Facts about coaches from Rome to Brussels

Compare all providers like FlixBus that travel 16 times every day by bus from Rome to Brussels in one click! Book your bus ticket from Rome to Brussels starting from £55!

Cheapest Bus	£55
Fastest Bus	22h 30m
Earliest Coach	10:40
Latest Coach	23:35
Daily Bus Connections	16 Ø
Distance	1,173.4 km
Coach Companies	FlixBus

Cheapest coach connections from Rome to Brussels

Every day, 16 buses from 1 coach companies leave Rome for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 22/12/2025 and for the following days.

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday

Monday 22/12

£106

Tuesday 23/12

£105

Wednesday 24/12

£98

Thursday 25/12

Friday 26/12

£145

Saturday 27/12

£146

Sunday 28/12

£148

Monday 29/12

£138

Tuesday 30/12

£118

Wednesday 31/12

£102

Thursday 01/01

£136

Friday 02/01

£169

Saturday 03/01

£130

Sunday 04/01

Monday 05/01

Tuesday 06/01

Wednesday 07/01

Thursday 08/01

Friday 09/01

Saturday 10/01

Sunday 11/01

£55

Monday 12/01

Tuesday 13/01

Wednesday 14/01

Thursday 15/01

Friday 16/01

Saturday 17/01

Sunday 18/01

The cheapest time to travel from Rome to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Brussels, for the next 30 days.

With a price starting from £55, Sunday is the cheapest day for a coach from Rome to Brussels. Friday instead is the most expensive day with prices starting from £145.

Night is the cheapest day time for bus tickets from Rome to Brussels, with £55. Afternoon is the most expensive time of the day with prices starting from £105.

How to save money travelling from Rome to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Rome to Brussels are also emptier.

All bus stations and stops in Rome and Brussels

The map below shows you where to find all the bus stations in Rome and Brussels.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Largo Guido Mazzoni 4

Tiburtina Coach Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

Central Station

Delta

PONT DU, Boulevard des Invalides, 1160 BRUXELLES, Belgium

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Brussels? Compare all modes of transports from Rome to Brussels.

Service and Comfort on the bus from Rome to Brussels

Want to know which seat classes are available on the coaches from Rome to Brussels? Or which bus companies serve the route Rome to Brussels? Below you will find answers to your questions.

FAQs about the Rome to Brussels bus

How much does a Rome - Brussels coach trip cost?

This depends on, among other things, the day and travel time. The cheapest ticket for the Rome - Brussels bus trip is available from £55 and takes 32h 25m. Compare offers and save money!

How much could I save by comparing buses from Rome to Brussels?

The connection Rome to Brussels is offered by 1 companies with ticket prices ranging from £55 to £219. Therefore, we suggest booking your ticket as soon as possible to ensure you will get the cheapest ticket price.

How many connections are available for the Rome - Brussels route on average every day?

Each day, the bus route from Rome to Brussels is offered by roughly 16 busses. By using our search, you can compare bus schedules and find your ideal trip.

How long does a bus to Brussels from Rome take?

The quickest coach from Rome to Brussels is provided by FlixBus and takes 22h 30m. Coach tickets for this connection cost £147. However, keep in mind that the connection can take longer due to traffic.

What time is the first bus from Rome to Brussels?

The earliest bus to Brussels departs from Rome at 10:40. In this context, information about departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

What time is the last coach from Rome to Brussels?

The latest bus to Brussels departs from Rome at 23:35. Please note that departure times may differ on weekends and holidays. Simply use our search to find the exact times for your planned travel date.

Which bus companies serve the Rome - Brussels route?

Passengers looking to travel from Rome to Brussels can travel with FlixBus. Compare all available bus tickets with our search to book the trip that works best for you.

Is there a direct bus between Rome and Brussels?

You can check all the direct connections between Rome and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the bus to Brussels from Rome?

Depending on which provider you travel with, what you are allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the bus for the Rome Brussels bus route free of charge. Simply use our search to find a coach that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make travelling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Brussels on your planned travel date.

How does CheckMyBus find the best bus deals from Rome to Brussels?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between Rome and Brussels. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Rome to Brussels?

Prices and availability for 16 trips between Rome and Brussels change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Rome to Brussels

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Brussels

Here’s an overview of the most popular bus routes to Rome and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!