Compare all timetables for the bus from Santiago, RM to La Serena
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 | Santiago, RM | Sur Bus Station | 17:00 | La Serena | Central Coach Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 14/12/2025 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 14/12/2025 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 30m | 12:00 | Santiago, RM | Terminal San Borja | 18:30 | La Serena | Central Coach Station | Premium Economy | £10 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 14/12/2025 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 14/12/2025 18:30:00. 50 Premium Economy ticket for £10 per person are available. Travel duration is 6h 30m
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| Turbus | 7h 10m | 06:55 | Santiago, RM | Terminal Alameda | 14:05 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £12 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 14/12/2025 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 14/12/2025 14:05:00. 50 Premium Economy ticket for £12 per person are available. Travel duration is 7h 10m
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| FlixBus | 6h 5m | 06:15 | Santiago, RM | Terminal San Borja | 12:20 | La Serena | Central Coach Station | Economy | £12 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 14/12/2025 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 14/12/2025 12:20:00. 50 Economy ticket for £12 per person are available. Travel duration is 6h 5m
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| Pullman Bus | 6h 20m | 11:00 | Santiago, RM | Terminal San Borja | 17:20 | La Serena | El Sto, 1060 | First Class | £12 |
A Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 14/12/2025 11:00:00 to El Sto, 1060, La Serena (Chile) arriving at 14/12/2025 17:20:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 | Santiago, RM | Terminal San Borja | 17:00 | La Serena | Central Coach Station | Business | £8 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 15/12/2025 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 15/12/2025 17:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 10m | 13:00 | Santiago, RM | Terminal San Borja | 19:10 | La Serena | Central Coach Station | Premium Economy | £9 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 15/12/2025 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 15/12/2025 19:10:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| FlixBus | 6h 10m | 06:15 | Santiago, RM | Terminal San Borja | 12:25 | La Serena | Central Coach Station | Economy | £10 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 15/12/2025 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 15/12/2025 12:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 10m
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| Turbus | 7h 10m | 06:55 | Santiago, RM | Terminal Alameda | 14:05 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £13 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 15/12/2025 06:55:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 15/12/2025 14:05:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 7h 10m
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| Pullman San Andres | 6h 15m | 15:30 | Santiago, RM | Terminal San Borja | 21:45 | La Serena | Central Coach Station | Premium Economy | £13 |
A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 15/12/2025 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 15/12/2025 21:45:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 15m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 | Santiago, RM | Sur Bus Station | 17:00 | La Serena | Central Coach Station | Premium Economy | £7 |
A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 16/12/2025 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 16/12/2025 17:00:00. 50 Premium Economy ticket for £7 per person are available. Travel duration is 6h 30m
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| FlixBus | 6h 10m | 06:15 | Santiago, RM | Terminal San Borja | 12:25 | La Serena | Central Coach Station | Economy | £9 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 16/12/2025 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 16/12/2025 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| Cormar Bus | 6h 30m | 12:00 | Santiago, RM | Terminal San Borja | 18:30 | La Serena | Central Coach Station | Premium Economy | £9 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 16/12/2025 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 16/12/2025 18:30:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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| Turbus | 6h 25m | 07:20 | Santiago, RM | Terminal Alameda | 13:45 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £13 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 16/12/2025 07:20:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 16/12/2025 13:45:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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| Nueva Andimar Vip | 6h 0m | 07:50 | Santiago, RM | Terminal San Borja | 13:50 | La Serena | Central Coach Station | Economy | £13 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 16/12/2025 07:50:00 to Central Coach Station, La Serena (Chile) arriving at 16/12/2025 13:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 0m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 | Santiago, RM | Terminal San Borja | 17:00 | La Serena | Central Coach Station | Business | £8 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 17/12/2025 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 17/12/2025 17:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 30m
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| FlixBus | 6h 10m | 06:15 | Santiago, RM | Terminal San Borja | 12:25 | La Serena | Central Coach Station | Economy | £9 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 17/12/2025 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 17/12/2025 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| Cormar Bus | 6h 10m | 13:00 | Santiago, RM | Terminal San Borja | 19:10 | La Serena | Central Coach Station | Premium Economy | £9 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 17/12/2025 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 17/12/2025 19:10:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| Turbus | 6h 25m | 07:20 | Santiago, RM | Terminal Alameda | 13:45 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £13 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 17/12/2025 07:20:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 17/12/2025 13:45:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 25m
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| Pullman San Andres | 6h 15m | 14:00 | Santiago, RM | Terminal San Borja | 20:15 | La Serena | Central Coach Station | Premium Economy | £13 |
A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 17/12/2025 14:00:00 to Central Coach Station, La Serena (Chile) arriving at 17/12/2025 20:15:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 15m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Turbus | 6h 20m | 06:10 | Santiago, RM | Terminal Alameda | 12:30 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £8 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 18/12/2025 06:10:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 18/12/2025 12:30:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 20m
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| Buses Romani | 6h 30m | 10:30 | Santiago, RM | Terminal San Borja | 17:00 | La Serena | Central Coach Station | Business | £8 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 18/12/2025 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 18/12/2025 17:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 30m
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| FlixBus | 6h 10m | 06:15 | Santiago, RM | Terminal San Borja | 12:25 | La Serena | Central Coach Station | Economy | £9 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 18/12/2025 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 18/12/2025 12:25:00. 50 Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| Cormar Bus | 6h 10m | 13:00 | Santiago, RM | Terminal San Borja | 19:10 | La Serena | Central Coach Station | Premium Economy | £9 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 18/12/2025 13:00:00 to Central Coach Station, La Serena (Chile) arriving at 18/12/2025 19:10:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| Nueva Andimar Vip | 6h 0m | 07:50 | Santiago, RM | Terminal San Borja | 13:50 | La Serena | Central Coach Station | Economy | £13 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 18/12/2025 07:50:00 to Central Coach Station, La Serena (Chile) arriving at 18/12/2025 13:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 0m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Turbus | 6h 25m | 07:20 | Santiago, RM | Terminal Alameda | 13:45 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £8 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 19/12/2025 07:20:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 19/12/2025 13:45:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 25m
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| Buses Romani | 6h 30m | 10:30 | Santiago, RM | Terminal San Borja | 17:00 | La Serena | Central Coach Station | Business | £8 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 19/12/2025 10:30:00 to Central Coach Station, La Serena (Chile) arriving at 19/12/2025 17:00:00. 50 Business ticket for £8 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 30m | 12:00 | Santiago, RM | Terminal San Borja | 18:30 | La Serena | Central Coach Station | Premium Economy | £9 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 19/12/2025 12:00:00 to Central Coach Station, La Serena (Chile) arriving at 19/12/2025 18:30:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 30m
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| FlixBus | 6h 10m | 06:15 | Santiago, RM | Terminal San Borja | 12:25 | La Serena | Central Coach Station | Economy | £10 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 19/12/2025 06:15:00 to Central Coach Station, La Serena (Chile) arriving at 19/12/2025 12:25:00. 50 Economy ticket for £10 per person are available. Travel duration is 6h 10m
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| Pullman San Andres | 6h 15m | 07:00 | Santiago, RM | Terminal San Borja | 13:15 | La Serena | Central Coach Station | Premium Economy | £13 |
A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 19/12/2025 07:00:00 to Central Coach Station, La Serena (Chile) arriving at 19/12/2025 13:15:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 15m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Turbus | 6h 10m | 18:30 | Santiago, RM | Terminal Alameda | 00:40 | La Serena | Avda. Fco de Aguirre Station | Premium Economy | £8 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 20/12/2025 18:30:00 to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 21/12/2025 00:40:00. 50 Premium Economy ticket for £8 per person are available. Travel duration is 6h 10m
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| FlixBus | 6h 10m | 18:10 | Santiago, RM | Terminal San Borja | 00:20 | La Serena | Central Coach Station | Premium Economy | £9 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 20/12/2025 18:10:00 to Central Coach Station, La Serena (Chile) arriving at 21/12/2025 00:20:00. 50 Premium Economy ticket for £9 per person are available. Travel duration is 6h 10m
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| Cormar Bus | 6h 30m | 08:30 | Santiago, RM | Terminal San Borja | 15:00 | La Serena | Central Coach Station | First Class | £12 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 20/12/2025 08:30:00 to Central Coach Station, La Serena (Chile) arriving at 20/12/2025 15:00:00. 50 First Class ticket for £12 per person are available. Travel duration is 6h 30m
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| Nueva Andimar Vip | 6h 0m | 07:50 | Santiago, RM | Terminal San Borja | 13:50 | La Serena | Central Coach Station | Economy | £13 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 20/12/2025 07:50:00 to Central Coach Station, La Serena (Chile) arriving at 20/12/2025 13:50:00. 50 Economy ticket for £13 per person are available. Travel duration is 6h 0m
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| Pullman San Andres | 6h 15m | 15:30 | Santiago, RM | Terminal San Borja | 21:45 | La Serena | Central Coach Station | Premium Economy | £13 |
A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 20/12/2025 15:30:00 to Central Coach Station, La Serena (Chile) arriving at 20/12/2025 21:45:00. 50 Premium Economy ticket for £13 per person are available. Travel duration is 6h 15m
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Best Price Offer: The price for the cheapest coach from Santiago, RM to La Serena is £7 on 14/12/2025. Flexible travellers save on ticket prices.
Frequency of bus connections between Santiago, RM and La Serena
Facts about coaches from Santiago, RM to La Serena
Compare all providers like FlixBus, Pullman Bus and Turbus that travel 261 times every day by bus from Santiago, RM to La Serena in one click! Book your bus ticket from Santiago, RM to La Serena starting from £7!
| Cheapest Bus | £7 |
| Fastest Bus | 5h 30m |
| Earliest Coach | 06:10 |
| Latest Coach | 23:59 |
| Daily Bus Connections | 261 Ø |
| Distance | 397.3 km |
| Coach Companies | FlixBus, Pullman Bus, Turbus, Pullman San Andres, Cikbus Elité, Pluss Chile, Cormar Bus, Condor Bus, Nueva Andimar Vip, Buses Romani and 4 more. |
Cheapest coach connections from Santiago, RM to La Serena
Every day, 261 buses from 14 coach companies leave Santiago, RM for La Serena: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 14/12/2025 and for the following days.
The cheapest time to travel from Santiago, RM to La Serena
How to save money travelling from Santiago, RM to La Serena
Book the ticket from Santiago, RM to La Serena in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to La Serena, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later coaches from Santiago, RM to La Serena are also emptier.Latest reviews for coach companies on the route Santiago, RM - La Serena
All bus stations and stops in Santiago, RM and La Serena
The map below shows you where to find all the bus stations in Santiago, RM and La Serena.
Compare the bus with other modes of transport
Service and Comfort on the bus from Santiago, RM to La Serena
FAQs about the Santiago, RM to La Serena bus
How much does a Santiago, RM - La Serena coach trip cost?
How much could I save by comparing buses from Santiago, RM to La Serena?
How many connections are available for the Santiago, RM - La Serena route on average every day?
How long does a bus to La Serena from Santiago, RM take?
What time is the first bus from Santiago, RM to La Serena?
What time is the last coach from Santiago, RM to La Serena?
Which bus companies serve the Santiago, RM - La Serena route?
Is there a direct bus between Santiago, RM and La Serena?
What can I take with me on the bus to La Serena from Santiago, RM?
What equipment is available for the Santiago, RM La Serena bus route?
Available seat classes which are offered on the bus route Santiago, RM to La Serena
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
Comfortable seating, food and drink service, accompanied generally by ticket flexibility.
Best of the best: you will find the most comfortable accommodation to work or relax during your travel.
More bus routes to Santiago, RM and to La Serena
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- Bus Routes to La Serena
- Bus to La Serena from Alto Hospicio
- Bus Antofagasta to La Serena
- Calama to La Serena bus
- Concepción to La Serena bus
- Buses Diego de Almagro to La Serena
- Bus from La Calera to La Serena
- Bus Los Vilos to La Serena
- Coach from Mendoza to La Serena
- Coaches Ovalle to La Serena
- Bus to La Serena from Pozo Almonte
- Quilpué to La Serena bus
- Buses Rancagua to La Serena
- Coaches San Juan, SJ to La Serena
- Coach from Sierra Gorda to La Serena
- Bus to La Serena from Talca, ML
- Bus Temuco to La Serena
- Coach Tocopilla to La Serena
- Coach to La Serena from Vallenar
- Bus to La Serena from Viña del Mar

